Amirkabir University of Technology Amirkabir Journal of Mechanical Engineering 2008-6032 52 12 2019 10 16 Study of Young’s Modulus and Failure Strength of Polyurethane-Based Binary Polymer Composite Structures Based on Stress-Strain Curve for Tissue Engineering Vascular Graft Application Study of Young’s Modulus and Failure Strength of Polyurethane-Based Binary Polymer Composite Structures Based on Stress-Strain Curve for Tissue Engineering Vascular Graft Application 3567 3582 3638 10.22060/mej.2019.16159.6288 FA Nafiseh Jirofti Chemical Engineering Department, University of Sistan and Baluchestan, Zahedan, Iran Davod Mohebbi-Kalhori Chemical Engineering Department, University of Sistan and Baluchestan, Zahedan, Iran Afra Hajdizadeh Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran Abdolreza Samimi aC Chemical Engineering Department, University of Sistan and Baluchestan, Zahedan, Iran Journal Article 2019 04 17 The coronary arteries are of the important cardiovascular diseases. The autograft is the main treatment for this problem, but in many patients, the autografts are not applicable. So, due to a large number of requirements, it needs to find suitable replacements for diseases of blood vessels. Nanomaterial structures are highly contributive in tissue engineering vascular scaffolds due to their ability in mimicking the nanoscale dimension of the natural extracellular matrix and the existing mechanical match between the native vessel and the structure. The aim of this research was developing and mechanically improving nanofibrous hybrid structures using blend electrospinning methods with different ratios of the polyethylene terephthalate, polyurethane and polycaprolactone. The morphological and mechanical properties of all fabricated structures were evaluated. The average fiber diameter, porosity, stress and Young’s modulus changes’ range in composite structures (polycaprolactone/polyurethane and polyethylene terephthalate/polyurethane ) were obtained 343 ± 94 to 382 ± 83 nm, 58.6 ± 3.12 to 81 ± 1.7 %, 2.66 ± 0.39 to 19.05 ± 3.2 MPa and 3.18 ± 0.09 to 41.4± 3.31 MPa, respectively. According to results, the fabricated scaffolds as well as polyethylene terephthalate/polyurethane structure exhibited suitable mechanical and biological properties and clinical requirements as a small-diameter vascular graft. The coronary arteries are of the important cardiovascular diseases. The autograft is the main treatment for this problem, but in many patients, the autografts are not applicable. So, due to a large number of requirements, it needs to find suitable replacements for diseases of blood vessels. Nanomaterial structures are highly contributive in tissue engineering vascular scaffolds due to their ability in mimicking the nanoscale dimension of the natural extracellular matrix and the existing mechanical match between the native vessel and the structure. The aim of this research was developing and mechanically improving nanofibrous hybrid structures using blend electrospinning methods with different ratios of the polyethylene terephthalate, polyurethane and polycaprolactone. The morphological and mechanical properties of all fabricated structures were evaluated. The average fiber diameter, porosity, stress and Young’s modulus changes’ range in composite structures (polycaprolactone/polyurethane and polyethylene terephthalate/polyurethane ) were obtained 343 ± 94 to 382 ± 83 nm, 58.6 ± 3.12 to 81 ± 1.7 %, 2.66 ± 0.39 to 19.05 ± 3.2 MPa and 3.18 ± 0.09 to 41.4± 3.31 MPa, respectively. According to results, the fabricated scaffolds as well as polyethylene terephthalate/polyurethane structure exhibited suitable mechanical and biological properties and clinical requirements as a small-diameter vascular graft. https://mej.aut.ac.ir/article_3638_895daa408f494ad58006c47a30f51c1f.pdf