Amirkabir University of Technology Amirkabir Journal of Mechanical Engineering 2008-6032 53 2 2021 04 21 Mechanical Properties and Structural Behavior of Bone at Nano Scale with Cohesive Element Mechanical Properties and Structural Behavior of Bone at Nano Scale with Cohesive Element 745 776 3768 10.22060/mej.2020.16827.6448 FA Elham Alizadeh Faculty of Civil Engineering, Babol Noshirvani University of Technology, Babol, Iran Mehdi Dehestani Faculty of Civil Engineering, Babol Noshirvani University of Technology, Babol, Iran Philippe Zysset Professor of Biomechanics, University of Bern, Switzerland Journal Article 2019 07 25 Bone is a biological tissue whose main components are different from the mechanical aspect. Some of the bone diseases are due to mutations in the bone structure at the nano scale, while their clinical symptoms appear at the macro scale. Therefore, the evaluation of bone at micro and nano scales is important. In the current study, the finite element modeling is performed to evaluate the mechanical properties and behavior of bone at the nano scale and the cohesive element is applied. After its verification, the stress distribution and elastic properties are compared with the analytical model. Limited studies are available on strain ratio and it is presented for different cohesive elements in the current study. The influence of mineral volume fraction and mechanical properties of collagen is investigated. The comparison between finite element models and the other ones demonstrate an excellent agreement. The collagen- hydroxyapatite interface with unknown mechanical properties is the most important parameter in the model and the thick water layer with Van der Waals interaction and viscous shear is determined as the most probable cohesive layer. The parametric studies indicate the significant effect of nonlinear collagen on the model. To decrease the calculation in models, the proposed unit cell with periodic boundary conditions could be employed. Bone is a biological tissue whose main components are different from the mechanical aspect. Some of the bone diseases are due to mutations in the bone structure at the nano scale, while their clinical symptoms appear at the macro scale. Therefore, the evaluation of bone at micro and nano scales is important. In the current study, the finite element modeling is performed to evaluate the mechanical properties and behavior of bone at the nano scale and the cohesive element is applied. After its verification, the stress distribution and elastic properties are compared with the analytical model. Limited studies are available on strain ratio and it is presented for different cohesive elements in the current study. The influence of mineral volume fraction and mechanical properties of collagen is investigated. The comparison between finite element models and the other ones demonstrate an excellent agreement. The collagen- hydroxyapatite interface with unknown mechanical properties is the most important parameter in the model and the thick water layer with Van der Waals interaction and viscous shear is determined as the most probable cohesive layer. The parametric studies indicate the significant effect of nonlinear collagen on the model. To decrease the calculation in models, the proposed unit cell with periodic boundary conditions could be employed. https://mej.aut.ac.ir/article_3768_28d437661d95291767e7402dfe969962.pdf