Amirkabir University of Technology Amirkabir Journal of Mechanical Engineering 2008-6032 54 3 2022 05 22 Computational Modeling of Intraperitoneal Drug Delivery for the Treatment of Peritoneal Carcinomatosis Computational Modeling of Intraperitoneal Drug Delivery for the Treatment of Peritoneal Carcinomatosis 687 702 4605 10.22060/mej.2021.19881.7141 FA Mohsen Rezaeian Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran 0000-0003-4427-9720 Majid Soltani Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran 0000-0003-0878-6274 Journal Article 2021 04 21 Intraperitoneal injection of chemotherapy has been proposed as a promising method for the treatment of peritoneal metastasis, and its use in conjunction with cytoreductive surgery has shown interesting results in the treatment of patients. However, drug penetration into the tumor is limited in this method, and a better understanding of the factors influencing this low penetration depth is necessary. For this purpose, in the present study, a numerical model has been developed to investigate drug transport during intraperitoneal chemotherapy. Using this model, first, the Spatio-temporal distribution of free, bound and internalized drug concentrations are calculated. Then, by calculating the drug penetration depth and the fraction of killed cells, the effectiveness of the treatment is evaluated. Results of a 10mm tumor after 60 minutes of treatment showed that the drug is available only in a limited area of the outer region of the tumor. The values of fraction of killed cells and drug penetration depth were 1.2% and 11.4%, respectively, which indicates a poor treatment efficiency. The findings of this paper can be used in future numerical and experimental studies to gain a deeper insight into the mechanisms of drug delivery to the tumor by intraperitoneal injection. Intraperitoneal injection of chemotherapy has been proposed as a promising method for the treatment of peritoneal metastasis, and its use in conjunction with cytoreductive surgery has shown interesting results in the treatment of patients. However, drug penetration into the tumor is limited in this method, and a better understanding of the factors influencing this low penetration depth is necessary. For this purpose, in the present study, a numerical model has been developed to investigate drug transport during intraperitoneal chemotherapy. Using this model, first, the Spatio-temporal distribution of free, bound and internalized drug concentrations are calculated. Then, by calculating the drug penetration depth and the fraction of killed cells, the effectiveness of the treatment is evaluated. Results of a 10mm tumor after 60 minutes of treatment showed that the drug is available only in a limited area of the outer region of the tumor. The values of fraction of killed cells and drug penetration depth were 1.2% and 11.4%, respectively, which indicates a poor treatment efficiency. The findings of this paper can be used in future numerical and experimental studies to gain a deeper insight into the mechanisms of drug delivery to the tumor by intraperitoneal injection. https://mej.aut.ac.ir/article_4605_971eb27c6345932b82b70414028d7183.pdf