Amirkabir University of Technology Amirkabir Journal of Mechanical Engineering 2008-6032 54 11 2023 01 21 Numerical Study of Therapeutic Effectiveness of Bolus Injection and Continuous Infusion on Drug Delivery to Vascularized Solid Tumor Numerical Study of Therapeutic Effectiveness of Bolus Injection and Continuous Infusion on Drug Delivery to Vascularized Solid Tumor 2543 2560 5003 10.22060/mej.2022.21266.7412 FA Majid Soltani Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran 0000-0003-0878-6274 Mohammad Kiani Shahvandi Department of Mechanical Engineering, K N Toosi University of Technology, Tehran, Iran Journal Article 2022 04 04 Effective delivery of drugs to tumor cells is essential for the success of most anticancer therapies. In this study, two-dimensional modeling for spatiotemporal distribution of doxorubicin concentration under bolus injection and the continuous infusion is presented. Mathematical simulations have been performed considering the main physical and biochemical processes in drug delivery to tumor cells. Anticancer effectiveness is evaluated through changes in tumor cell density based on predicted intracellular concentrations. Unlike most computational models, which assume a uniform distribution of blood vessels in the tumor, the vascular network is produced using a sprouting angiogenesis method. The results demonstrate that the drugs accumulate more in areas with high vascular density, resulting in improved drug cytotoxicity. Compared to bolus injection, continuous infusion leads to longer high level maintenance of intracellular drug concentrations in the tumor, which is more effective in improving the cytotoxic effect. Although bolus injection leads to a 90% higher extracellular concentration peak, there is the risk of severe side effects. Also, continuous infusion by keeping doxorubicin at a higher level in the tumor leads to improved anticancer effectiveness by about 26% relative to the effectiveness of bolus injection at the end of the treatment.<br />  Effective delivery of drugs to tumor cells is essential for the success of most anticancer therapies. In this study, two-dimensional modeling for spatiotemporal distribution of doxorubicin concentration under bolus injection and the continuous infusion is presented. Mathematical simulations have been performed considering the main physical and biochemical processes in drug delivery to tumor cells. Anticancer effectiveness is evaluated through changes in tumor cell density based on predicted intracellular concentrations. Unlike most computational models, which assume a uniform distribution of blood vessels in the tumor, the vascular network is produced using a sprouting angiogenesis method. The results demonstrate that the drugs accumulate more in areas with high vascular density, resulting in improved drug cytotoxicity. Compared to bolus injection, continuous infusion leads to longer high level maintenance of intracellular drug concentrations in the tumor, which is more effective in improving the cytotoxic effect. Although bolus injection leads to a 90% higher extracellular concentration peak, there is the risk of severe side effects. Also, continuous infusion by keeping doxorubicin at a higher level in the tumor leads to improved anticancer effectiveness by about 26% relative to the effectiveness of bolus injection at the end of the treatment.<br />  https://mej.aut.ac.ir/article_5003_240ac9371ec2671ae99847c3ae2e6384.pdf