Amirkabir University of Technology Amirkabir Journal of Mechanical Engineering 2008-6032 54 12 2023 02 20 Three Dimensional Design and Finite Element Analysis of Scaffold for Use in Damaged Bone Tissue Three Dimensional Design and Finite Element Analysis of Scaffold for Use in Damaged Bone Tissue 2801 2820 5065 10.22060/mej.2023.21309.7421 FA Mohammad Javad Khoshgoftar Department of Mechanical Engineering, Arak University, Arak, Iran 0000-0002-7942-6877 Hamidreza Ansari Department of Mechanical Engineering, Arak University, Arak, Iran Journal Article 2022 04 18 Major bone defects, especially in long bones such as the femur, which can result from trauma, tumor, or bone infection, are among the most common injuries a person faces daily. This research presents a practical and accurate process for designing bone tissue engineering scaffolds to treat bone injuries. For this purpose, computed tomography-Scan images of the area related to the human femur were obtained. A bone defect caused by bone damage was made in the cortical and trabecular parts. Next, the outer surface of the damaged parts was designed with an ideal geometry. The design of the unit building cell of the internal structure of the scaffold was also done with simple cubic geometry. Finite element analysis was used to investigate the effect of porosity on the Young modulus of the unit cell. Finally, using the results of finite element analysis, a unit cell with an edge size of 0.972 mm and pore size of 0.6 mm was designed to reconstruct the cortical part, and a unit cell with an edge size of 0.972 mm and a strut thickness of 0.165 mm was designed to rebuild the trabecular part. The scaffold designed in this study has a geometry that matches the geometry of the damaged part in its ideal state and provides the necessary conditions for cell proliferation and diffusion of nutrients. Major bone defects, especially in long bones such as the femur, which can result from trauma, tumor, or bone infection, are among the most common injuries a person faces daily. This research presents a practical and accurate process for designing bone tissue engineering scaffolds to treat bone injuries. For this purpose, computed tomography-Scan images of the area related to the human femur were obtained. A bone defect caused by bone damage was made in the cortical and trabecular parts. Next, the outer surface of the damaged parts was designed with an ideal geometry. The design of the unit building cell of the internal structure of the scaffold was also done with simple cubic geometry. Finite element analysis was used to investigate the effect of porosity on the Young modulus of the unit cell. Finally, using the results of finite element analysis, a unit cell with an edge size of 0.972 mm and pore size of 0.6 mm was designed to reconstruct the cortical part, and a unit cell with an edge size of 0.972 mm and a strut thickness of 0.165 mm was designed to rebuild the trabecular part. The scaffold designed in this study has a geometry that matches the geometry of the damaged part in its ideal state and provides the necessary conditions for cell proliferation and diffusion of nutrients. https://mej.aut.ac.ir/article_5065_ac0b236e346da355400a90fcc7e28be6.pdf