عنوان مقاله [English]
Study of axonal behavior under different environmental conditions can provide a better insight into the development of therapeutic approaches for healing after nerve damages. By modeling of sublayer in the form of a hyperelastic material and applying different pressures, the amount of strains tolerated by axon was calculated. Strains were applied at three different time intervals to examine the effects of different strain rates. For axon, a model containing microtubules with linear elastic properties, neurofilament and axolemma with linear viscoelastic properties was considered. Finite elements method and comsol software were used for discretization of the sublayer and the substructures of the axon. It was observed that the fluid regime in the channel did not affect the mechanical response of the axon. The strain was close to zero (at most 0.0001) and the stress was also negligible (at most, 70 N/m2). The results showed the major effect of microtubules on resisting against mechanical forces and on the overall integrity of the axons. Most of the strains were seen inside the axolemma, indicating the importance of its mechanical response to injury. Regarding the response to the strain rate, the most probable damage to the axon, comparable with the former corresponding reports will occur at the strain of 42% and strain rate of 19.1 s-1, respectively.