نوع مقاله : مقاله پژوهشی
نویسندگان
1 گروه مهندسی برق- دانشکده فنی- دانشگاه بناب- بناب- ایران
2 گروه مهندسی برق، دانشکده فنی ُ دانشگاه بناب، بناب، ایران
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
The reliable separation of circulating tumor cells from blood cells is crucial for early cancer analysis and prediction. The aim of this research is the separation of circulating tumor cells and subtypes of white blood cells (Granulocytes and T-lymphocytes) by employing dielectrophoretic force. Dielectrophoresis refers to the movement of a neutral but polarizable particle, such as a cell, virus, or nanoparticle, in a non-uniform electric field. It is a powerful tool in microfluidics and lab-on-a-chip devices for cell sorting, such as separating cancer cells from blood cells or different types of bacteria. In this study, an innovative microfluidic device equipped with planar electrodes operating at a low voltage of 1 V for the main channel and 0.8 V for the second channel is proposed, which functions at a frequency of 100 kHz. The use of low voltage ensures the survival and health of biological cells, which is a key factor in medical applications. Plots of electrical potential, velocity, pressure, and the dielectrophoretic force applied to the three studied cell types were presented through simulations. The efficiency of the proposed microseparator for cancer cells was calculated to be approximately 94%. Subsequently, using the Finite Element Method as a comparative approach, the impact of changing the voltage of the main channel electrodes on the efficient separation of particles was investigated and analyzed.
کلیدواژهها [English]
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