بررسی عددی تأثیر میزان گرفتگی رگ کرونر چپ بر روی اکسیژن رسانی به بافت رگ

نوع مقاله : مقاله پژوهشی

نویسندگان

دانشگاه شیراز-مهندسی مکانیک/ گروه مهندسی مکانیک حرارت و سیالات

چکیده

 فعالیت و سوخت‌وساز سلول‌های بدن به شدت وابسته به تأمین پیوسته و کافی اکسیژن از طریق جریان خون می‌باشد. تحت شرایط مختلفی از جمله گرفتگی شریان‌ها، خونرسانی و اکسیژن‌رسانی به سلول‌ها می‌تواند تحت تأثیر قرار گیرد. در پژوهش حاضر به بررسی عددی انتقال اکسیژن در دیواره یک مدل دقیق از شریان کرونر چپ به همراه دو شاخه‌ اصلی در حالت بدون گرفتگی و درصدهای گرفتگی 75% و 84% پرداخته شده است. شبیه‌سازی‌ها با فرض جریان غیرنوسانی، سیال نیوتونی و دیواره صلب انجام شده است. در ابتدا به منظور صحت‌سنجی نتایج، توزیع غلظت اکسیژن درون رگ و همچنین در بافت رگ در یک حالت ساده با یکی از مراجع در این زمینه مقایسه شده است. نتایج نشان می‌دهد که به دلیل وجود انحنا، نیروهای گریز از مرکز و جریان ثانویه شکل می‌گیرد که در نتیجه‌ی آن کاهش قابل‌ملاحظه انتقال جرم اکسیژن به دیواره‌ در سمت انحنای داخلی رگ در مقایسه با دیواره در سمت انحنای خارجی دیده می‌شود. گرفتگی‌های رگ باعث به‌وجودآمدن نواحی با غلظت کم اکسیژن می‌شود و کمترین مقدار فشار جزئی در حدود 3 تا 4 میلی‌متر جیوه در مکان‌های مختلف تغییر می‌کند که احتمال رخ‌دادن هایپوکسیا در این نواحی زیادتر می‌شود. نتایج نشان می‌دهد که با افزایش و کاهش 8/12درصدی برای پارامتر P50 تأثیر بسیار ناچیزی بر توزیع غلظت اکسیژن در دیواره‌ی رگ و داخل رگ دارد.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Numerical study of the effect of left coronary artery stenosis on vascular tissue oxygenation

نویسندگان [English]

  • Hossian Amjadi Manesh
  • Omid Reza Abbasi
  • Hossein Ali Pakravan
  • Omid AbouAli
School of Mechanical Engineering, Shiraz University, Shiraz, Iran
چکیده [English]

Cellular metabolism is strongly dependent on the sufficient and continuous supply of oxygen. Cellular oxygenation is performed by blood flow. Blood flow and oxygen delivery to cells can be influenced under several conditions such as arterial stenosis. In the present study, the oxygen delivery to the arterial wall of a precise model of the main left coronary artery  and its two main branches for normal artery and stenosis degrees of 75% and 84% is numerically investigated. For all simulations, it is assumed that the flow is steady, blood is Newtonian, and the arterial wall is rigid. Transported oxygen by hemoglobin as well as oxygen consumption in the vessel wall are considered for determining the oxygen content in the vascular tissue. The results of oxygen concentration in the lumen and vascular tissue are validated with a benchmark study. The results indicate that centrifugal forces and secondary flow are formed due to curvature and results in a significant reduction in the mass transfer of oxygen to the myocardial wall relative to the epicardial one. Arterial stenosis results in locations of low oxygen concentration with 3-4 mmHg less than the normal artery, that increases the likelihood of hypoxia in these areas. Finally, the results show that 12.8% reduction in P50 does not have a significant effect on the oxygen concentration in the lumen and vascular tissue.

کلیدواژه‌ها [English]

  • Left coronary artery stenosis
  • oxygen mass transfer
  • Left anterior descending artery
  • Circumflex branch of the left coronary
  • partial pressure of oxygen
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