مقایسه شریان‌های کاروتید طبیعی و مصنوعی در حالت‌های سالم و گرفته با درنظر گرفتن اثر خون بر دیواره الاستیک رگ

نوع مقاله : مقاله پژوهشی

نویسندگان

1 استادیار، گروه مهندسی مکانیک، مرکز آموزش عالی شهرضا، شهرضا 41143-86481، ایران

2 دانشجوی کارشناسی ارشد، دانشکده مهندسی مکانیک، دانشگاه صنعتی اصفهان، اصفهان، ایران

چکیده

گرافت رگ مصنوعی از جمله پرکاربردترین جراحی‌ها در بدن انسان است که طی آن قسمت باریک شده و دارای گرفتگی رگ با پروتز مصنوعی جایگزین می‌شود. رفتار مکانیکی این پروتز باید بسیار نزدیک به رفتار طبیعی رگ باشد تا عملکرد مناسبی داشته باشد. شریان کاروتید از شریان‌های اصلی در تامین خون مغز انسان است. در این مقاله اثر سیال خون بر دیواره رگ پروتز و رگ طبیعی در حالت‌های سالم و دارای گرفتگی مورد بررسی و تحلیل قرار گرفته است. جریان خون به عنوان یک سیال غیرنیوتنی در شریان کاروتید با استفاده از نرم افزار انسیس سی‌اف‌ایکس شبیه‌سازی شده است. بر اساس نتایج بدست آمده، گرفتگی باعث افزایش سرعت، تنش برشی، تنش فون میزز، تغییر شکل و همچنین کاهش موضعی فشار در ناحیه گرفتگی می‌شود. بیشترین میزان تغییر شکل و تنش فون میزز در ناحیه نزدیک به انشعاب و در شاخه اصلی شریان کاروتید رخ می‌دهد. در ادامه مقاله از پلیمرهای داکرون و پلی‌اورتان به عنوان جایگزین شریان کاروتید طبیعی استفاده شده و میزان تنش فون میزز و مقدار تغییر شکل در این پلیمرها برای حالت‌های رگ سالم و گرفته محاسبه شده است. بر اساس نتایج بدست آمده استفاده از پلیمر داکرون به عنوان جایگزین شریان کاروتید طبیعی نسبت به پلیمر پلی‌اورتان مناسب‌تر است.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Comparison of natural and synthetic carotid arteries in the normal and occluded cases considering the effect of blood on elastic wall of artery

نویسندگان [English]

  • Hamed Bagheri-Esfeh 1
  • Sobhan Shanehsaz 2
1 Assistant professor, Department of Mechanical Engineering, Faculty of Engineering, University of Shahreza, Shahreza, Iran
2 MSc student, Department of Mechanical Engineering, Isfahan University of Technology, Isfahan, Iran
چکیده [English]

Artificial vein graft is one of the most commonly used surgeries in the human body, in which the stenosis is replaced with an artificial prosthesis. The mechanical behavior of this prosthesis must be very close to the normal behavior of the vein in order to have an appropriate operation. The carotid artery is one of the major arteries in the blood supply to the human brain. In this paper, the effect of blood fluid on natural and prosthetic vessel walls in normal and occluded cases has been analyzed. Blood flow as a non-Newtonian fluid in the carotid artery has been simulated using ANSYS CFX software. According to the obtained results, the stenosis increases the velocity, shear stress, von Mises stress, deformation as well as local pressure reduction in the occlusion zone. Maximum value of deformation and von Mises stress occurs near bifurcation in the common carotid artery. Then Dacron and polyurethane polymers have been used as replacements for natural carotid artery and von Mises stress and deformation values have been calculated for these polymers in the normal and occluded cases. According to the obtained results, usage of Dacron polymer as a replacement for the natural carotid artery is more appropriate than polyurethane.

کلیدواژه‌ها [English]

  • Blood flow
  • Non-Newtonian fluid
  • Carotid artery
  • Artificial graft
  • computational fluid dynamics
[1] J. Freischlag, N.A.S.C.E.T. Collaborators, Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis, New England Journal of Medicine, 325(7) (1991) 445-453.
[2] I. HajiGholami, B. FiroozAbadi, M.S. Saedi, Numerical simulation of mass transfer in the circulatory system, in:  22th Annual International Conference on Mechanical Engineering, ISME, Shahid Chamran University of Ahvaz, Ahvaz, Iran, 2014, (in Persian).
[3] D.D. Swartz, S.T. Andreadis, Animal models for vascular tissue-engineering, Current opinion in biotechnology, 24(5) (2013) 916-925.
[4] D. Young, Effect of a time-dependent stenosis on flow through a tube, Journal of Engineering for Industry, 90(2) (1968) 248-254.
[5] J.S. Lee, Y.C. Fung, Flow in locally constricted tubes at low Reynolds numbers, Journal of Applied Mechanics, 37(1) (1970) 9-16.
[6] B.E. Morgan, D.F. Young, An intergral method for the analysis of flow in arterial stenoses, Bulletin of Mathematical Biology, 36(1) (1974) 39-53.
[7] Q. Long, X.Y. Xu, U. Köhler, M.B. Robertson, I. Marshall, P. Hoskins, Quantitative comparison of CFD predicted and MRI measured velocity fields in a carotid bifurcation phantom, Biorheology, 39(3, 4) (2002) 467-474.
[8] M. Cibis, W.V. Potters, M. Selwaness, F.J. Gijsen, O.H. Franco, A.M.A. Lorza, M. de Bruijne, A. Hofman, A. van der Lugt, A.J. Nederveen, Relation between wall shear stress and carotid artery wall thickening MRI versus CFD, Journal of biomechanics, 49(5) (2016) 735-741.
[9] H. Gharahi, B.A. Zambrano, D.C. Zhu, J.K. DeMarco, S. Baek, Computational fluid dynamic simulation of human carotid artery bifurcation based on anatomy and volumetric blood flow rate measured with magnetic resonance imaging, International journal of advances in engineering sciences and applied mathematics, 8(1) (2016) 46-60.
[10] J. Moradicheghamahi, J. Sadeghiseraji, M. Jahangiri, Numerical solution of the Pulsatile, non-Newtonian and turbulent blood flow in a patient specific elastic carotid artery, International Journal of Mechanical Sciences, 150 (2018) 393-403.
[11] S.H. Lee, S. Kang, N. Hur, S.K. Jeong, A fluid-structure interaction analysis on hemodynamics in carotid artery based on patient-specific clinical data, Journal of mechanical science and technology, 26(12) (2012) 3821-3831.
[12] A.A. Nejad, Z. Talebi, D. Cheraghali, A. Shahbani-Zahiri, M. Norouzi, Pulsatile flow of non-Newtonian blood fluid inside stenosed arteries: Investigating the effects of viscoelastic and elastic walls, arteriosclerosis, and polycythemia diseases, Computer methods and programs in biomedicine, 154 (2018) 109-122.
[13] S.A. Khader, A. Ayachit, R. Pai, K. Ahmed, V. Rao, S.G. Kamath, Haemodynamics study in subject specific carotid bifurcation using FSI, International Journal of Mechanical and Mechatronics Engineering, 8(11) (2014) 1885-1890.
[14] D. Tang, Z. Teng, G. Canton, C. Yang, M. Ferguson, X. Huang, J. Zheng, P.K. Woodard, C. Yuan, Sites of rupture in human atherosclerotic carotid plaques are associated with high structural stresses: an in vivo MRI-based 3D fluid-structure interaction study, Stroke, 40(10) (2009) 3258-3263.
[15] Z. Teng, G. Canton, C. Yuan, M. Ferguson, C. Yang, X. Huang, J. Zheng, P.K. Woodard, D. Tang, 3D critical plaque wall stress is a better predictor of carotid plaque rupture sites than flow shear stress: an in vivo MRI-based 3D FSI study, Journal of biomechanical engineering, 132(3) (2010) 1-9.
[16] A. Carrel, Results of the permanent intubation of the thoracic aorta, Surgery, Gynecology & Obstetrics, 15 (1912) 245-248.
[17] A.H. Blakemore, A.B. Voorhees Jr, The use of tubes constructed from vinyon “N” cloth in bridging arterial defects-experimental and clinical, Annals of surgery, 140(3) (1954) 325-333.
[18] A. Moufarrej, J. Tordoir, B. Mees, Graft modification strategies to improve patency of prosthetic arteriovenous grafts for hemodialysis, The journal of vascular access, 17(1) (2016) 85-90.
[19] J.A. Akoh, Prosthetic arteriovenous grafts for hemodialysis, The journal of vascular access, 10(3) (2009) 137-147.
[20] A. García, E. Peña, A. Laborda, F. Lostalé, M. De Gregorio, M. Doblaré, M. Martínez, Experimental study and constitutive modelling of the passive mechanical properties of the porcine carotid artery and its relation to histological analysis: Implications in animal cardiovascular device trials, Medical engineering & physics, 33(6) (2011) 665-676.
[21] M. Lillie, R. Shadwick, J. Gosline, Mechanical anisotropy of inflated elastic tissue from the pig aorta, Journal of biomechanics, 43(11) (2010) 2070-2078.
[22] A. Versluis, A.J. Bank, W.H. Douglas, Fatigue and plaque rupture in myocardial infarction, Journal of biomechanics, 39(2) (2006) 339-347.
[23] J. Rotmans, E. Velema, H. Verhagen, J. Blankensteijn, J. Kastelein, D. De Kleijn, M. Yo, G. Pasterkamp, E. Stroes, Rapid, arteriovenous graft failure due to intimal hyperplasia: a porcine, bilateral, carotid arteriovenous graft model, Journal of Surgical Research, 113(1) (2003) 161-171.
[24] B.S. Kelly, S.C. Heffelfinger, J.F. Whiting, M.A. Miller, A. Reaves, J. Armstrong, A. Narayana, P. Roy-Chaudhury, Aggressive venous neointimal hyperplasia in a pig model of arteriovenous graft stenosis, Kidney international, 62(6) (2002) 2272-2280.
[25] S. Galego, F. Miranda Jr, J.P. Ortiz, K. De Lima Bessa, R.V. De Carvalho Fürst, E.Y. Fujii, O. Ramacciotti, Blood flow study of arteriovenous grafts with homologous and autologous veins in canine femoral vessels, The journal of vascular access, 7(1) (2006) 15-23.
[26] H. Bai, A. Dardik, Y. Xing, Decellularized carotid artery functions as an arteriovenous graft, Journal of Surgical Research, 234 (2019) 33-39.
[27] M. Domanin, A. Buora, F. Scardulla, B. Guerciotti, L. Forzenigo, P. Biondetti, C. Vergara, Computational fluid-dynamic analysis after carotid endarterectomy: patch graft versus direct suture closure, Annals of vascular surgery, 44 (2017) 325-335.
[28] I.D. Gavardinas, A. Athanasoulas, K. Spanos, A.D. Giannoukas, A.E. Giannakopoulos, Novel methods for the mechanical characterization of patches used in carotid artery repair, Materials Science and Engineering: C, 93(1) (2018) 640-648.
[29] C. Chen, Z. Ye, L. Luo, Y. Guo, Y. Chang, X. Ning, H. Wang, Carotid–Carotid Artery Crossover Bypass with a Synthetic Vascular Graft for Symptomatic Type 1A Common Carotid Artery Occlusion, World neurosurgery, 111 (2017) 286-293.
[30] L. Xue, H.P. Greisler, Biomaterials in the development and future of vascular grafts, Journal of vascular surgery, 37(2) (2003) 472-480.
[31] H. Bagheri-Esfeh, S. Shanehsaz, Study of carotid artery stenosis using CFD, in:  27th Annual International Conference on Mechanical Engineering ISME, Tarbiat Modares University, Tehran, Iran, 2019, (in Persian).
[32] F. Ajalloueian, M.L. Lim, G. Lemon, J.C. Haag, Y. Gustafsson, S. Sjöqvist, A. Beltrán-Rodríguez, C. Del Gaudio, S. Baiguera, A. Bianco, P. Jungebluth, P. Macchiarini, Biomechanical and biocompatibility characteristics of electrospun polymeric tracheal scaffolds, Biomaterials, 35(20) (2014) 5307-5315.
[33] S. Drilling, J. Gaumer, J. Lannutti, Fabrication of burst pressure competent vascular grafts via electrospinning: effects of microstructure, Journal of Biomedical Materials Research Part A, 88(4) (2009) 923-934.
[34] K. Kanokjaruvijit, T. Donprai, N. Phanthura, P. Noidet, J. Siripokharattana, Wall shear stress and velocity distributions in different types of stenotic bifurcations, Journal of Mechanical Science and Technology, 31(5) (2017) 2339-2349.
[35] M. Kim, T. Min, O. Kwon, H. Kim, T. Seto, Y. Kim, J.A. Kim, T. Kim, Numerical study on proximal ischemia, Journal of Mechanical Science and Technology, 29(12) (2015) 5523-5529.
[36] R.W. Fox, A.T. McDonald , P.J. Pritchard, Introduction to Fluid Mechanics, Wiley, 2003.
[37] M. Jahangiri, M. Saghafian, M. Sadeghi, Effects of non-Newtonian behavior of blood on wall shear stress in an elastic vessel with simple and consecutive stenosis, Biomedical and Pharmacology Journal, 8(1) (2015) 123-131.
[38] M. Jahangiri, M. Saghafian, M.R. Sadeghi, Numerical simulation of non-Newtonian models effect on hemodynamic factors of pulsatile blood flow in elastic stenosed artery, Journal of Mechanical Science and Technology, 31(2) (2017) 1003-1013.
[40] A.M. Robertson, A. Sequeira, R.G. Owens, Rheological models for blood, in:  Cardiovascular mathematics, Springer, 2009, pp. 211-241.
[41] M. Jahangiri, M. Saghafian, M.R. Sadeghi, Effect of six non-Newtonian viscosity models on hemodynamic parameters of pulsatile blood flow in stenosed artery, Journal of Computational and Applied Research in Mechanical Engineering, 7(2) (2018) 199-207.
[42] M. Jahangiri, A. Haghani, R. Ghaderi, S.M. Hosseini Harat, Effect of non-Newtonian models on blood flow in artery with different consecutive stenosis, International Journal of Advanced Design & Manufacturing Technology, 11(1) (2018) 89-96.
[43] K. Chandran, D. Gao, G. Han, H. Baraniewski, J. Corson, Finite-element analysis of arterial anastomoses with vein, Dacron and PTFE graffs, Medical and Biological Engineering and Computing, 30(4) (1992) 413-418.
[44] S.S. Chaurasia, R. Champakalakshmi, A. Li, R. Poh, X.W. Tan, R. Lakshminarayanan, C.T. Lim, D.T. Tan, J.S. Mehta, Effect of fibrin glue on the biomechanical properties of human Descemet's membrane, PloS one, 7(5) (2012) e37456.