عنوان مقاله [English]
Particle displacement in Nano-dimensions, improvement of properties, studies on cellular tissues are some of the applications of the nanomanipulation process. All of these applications are performed with an efficient tool called an atomic force microscopy. In general, the manipulation process begins with the contact of the probe and the desired cell tissue and with the application of force to the atomic force microscope. The increase in force will continue until it overcomes resistant forces such as friction. In this situation, the critical time and the critical force will be recorded. Examining all environmental and geometric factors and eliminating unnecessary parameters will lead to more accurate information in the field of cancer studies. Therefore, in this article, colon cancer tissue has been studied. The important parameter evaluated in this study is the critical force and time according to different friction models in order to reduce the damage to cancerous tissue. Experimental tests have been performed on colon cancer tissue using an atomic force microscope. LuGre, Coulomb and HK friction models are used in the simulations. Finally, by comparing the force outcome diagrams considering different friction models, in three-dimensional manipulation, the maximum amount of force and the critical time of manipulation of colon cancer tissue were recorded for the Coulomb friction model and the lowest value for the LuGre friction model.