طراحی سه بعدی و تحلیل المان محدود داربست مهندسی بافت به منظور کاربرد در درمان بافت استخوانی آسیب دیده

نوع مقاله : مقاله پژوهشی

نویسندگان

گروه مهندسی مکانیک، دانشکده فنی و مهندسی، دانشگاه اراک، اراک، ایران

چکیده

نقص‌های اساسی استخوان بویژه در استخوان‌های بلند مانند استخوان ران، که می‌توانند نتیجه ضربه، تومور و یا عفونت استخوان باشند، از متداول‌ترین آسیب‌هایی هستند که انسان در زندگی روزمره با آن‌ها روبه‌رو می‌شود. در این پژوهش، روندی کاربردی و با دقت مطلوب برای طراحی داربست مهندسی بافت استخوان برای کاربرد در درمان آسیب‌های استخوانی ارائه گردیده است. بدین منظور، تصاویر سی‌تی اسکن از ناحیه مربوط به استخوان ران انسان تهیه شد. با استفاده از این تصاویر، مدل‌های سه بعدی از قسمت‌های قشری و اسفنجی استخوان ران ساخته شد. یک نقص استخوانی ناشی از آسیب استخوان، در قسمت‌های قشری و اسفنجی ایجاد گردید. به منظور بررسی تأثیر تخلخل بر مدول یانگ سلول واحد، از تحلیل المان محدود استفاده شد. در نهایت با استفاده از نتایج حاصل از تحلیل المان محدود، سلول واحد با اندازه ضلع 0/972میلی‌متر و اندازه منفذ 0/6 میلی‌متر برای بازسازی قسمت قشری و سلول واحد با اندازه ضلع 0/972 میلی‌متر و اندازه ضخامت پایه 0/165 میلی متر برای بازسازی قسمت اسفنجی طراحی شده و در ساختار داربست مورد استفاده قرار گرفت. داربست طراحی شده در این پژوهش دارای هندسه‌ای منطبق بر هندسه قسمت آسیب دیده در حالت ایده‌آل خود بوده و به خوبی شرایط مورد نیاز برای تکثیر سلولی و انتشار مواد غذایی را فراهم می‌کند.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Three Dimensional Design and Finite Element Analysis of Scaffold for Use in Damaged Bone Tissue

نویسندگان [English]

  • Mohammad Javad Khoshgoftar
  • Hamidreza Ansari
Department of Mechanical Engineering, Arak University, Arak, Iran
چکیده [English]

Major bone defects, especially in long bones such as the femur, which can result from trauma, tumor, or bone infection, are among the most common injuries a person faces daily. This research presents a practical and accurate process for designing bone tissue engineering scaffolds to treat bone injuries. For this purpose, computed tomography-Scan images of the area related to the human femur were obtained. A bone defect caused by bone damage was made in the cortical and trabecular parts. Next, the outer surface of the damaged parts was designed with an ideal geometry. The design of the unit building cell of the internal structure of the scaffold was also done with simple cubic geometry. Finite element analysis was used to investigate the effect of porosity on the Young modulus of the unit cell. Finally, using the results of finite element analysis, a unit cell with an edge size of 0.972 mm and pore size of 0.6 mm was designed to reconstruct the cortical part, and a unit cell with an edge size of 0.972 mm and a strut thickness of 0.165 mm was designed to rebuild the trabecular part. The scaffold designed in this study has a geometry that matches the geometry of the damaged part in its ideal state and provides the necessary conditions for cell proliferation and diffusion of nutrients.

کلیدواژه‌ها [English]

  • Tissue engineering
  • Scaffold
  • Unit cell
  • Bone tissue
  • Bone injury treatment
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