Computational Investigation of the Effect of Adhesion between Cancer Cells and Vessel Walls on the Movement of the Cells in Blood Vessels

Document Type : Research Article

Authors

1 MSc/University of Tehran

2 Assistant professor/University of Tehran

3 MSc student/University of Tehran

Abstract

Cancer is a disease that causes mortality in the world. Despite of improvements in medicine, there is not still sufficient knowledge of cancer. Therefore, there is a strong need for engineering modeling to understand it. The motion and adhesion of cancer cells in a blood vessel during metastasis is a complex mechanism that occurs in body. A two[1]dimensional model of the movement of cancer cells has been developed that is solved in two different modes in a straight line in a blood vessel. These modes are related to presence and absence of adhesion between cancer cell and blood vessel wall in presence of adhesion between cancer cell and white blood cell. The analysis is performed using FEM and FSI equations. It is assumed that the properties of blood and cells are homogeneous and fluid is incompressible and Newtonian. Cancer cell is modeled as a rigid body and white blood cell is assumed as linear elastic. The analysis shows that the influence of adhesion between the cell and the vessel wall is more important from cell-cell adhesion. Through consideration in the adhesion charts along with medical issues such as drug delivery to patients can affect the treatment or prevention of metastasis.

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References

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Amirkabir Journal of Mechanical Engineering
Volume 51, Issue 6
January and February 2020
Pages 1271-1288

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