Numerical Study on the Complete Separation of Blood Cells using the Integrated Dielectrophoretic-Photophoretic Method in a New Microchannel

Document Type : Research Article

Authors

1 Faculty of Mechanical Engineering, Tarbiat Modares University, Tehran, Iran

2 Faculty of Electrical & Computer Engineering, Tarbiat Modares University, Tehran, Iran

3 Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Abstract

In the present study, a numerical simulation was conducted to investigate the separation of blood cells using an integrated dielectrophoretic-photophoretic method in a new microfluidic device. In this simulation, the migration behavior of human blood cells under laser radiation with a wavelength of 522 nm and in the presence of fluid flow has been investigated. Studies show that the photophoretic migration of red cells under the irradiation of laser beam is higher than platelets and other blood cells so that the magnitude of the applied photoelectric force on the red blood cells has been calculated about nine times that of the white blood cells under the irradiation of laser beam of 50. In this separation using photophoretic forces, red blood cells were first separated from the platelets and white cells. Subsequently, using the hydrodynamic forces induced by the fluid on the particles and the dielectrophoretic forces, the separation of the platelets from the white blood cells was carried out in different branches of the microchannel. The proposed design, in addition to high separation efficiency, has a negligible cell loss, so that it can be used as an effective method in many diagnostic processes and medical applications.

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Main Subjects


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