Numerical Simulation of Low-Density Lipoprotein Concentration Boundary Layer in a Straight Artery and the Effects of Wall Shear Stress

Document Type : Research Article

Authors

1 خیابان طالقانی، خیابان شهید ثلاث، ثلاث2، پلاک 38

2 Biomedical Eng. department, Amirkabir Univ. of Technology

Abstract

Low-density lipoprotein, which is recognized as bad cholesterol, typically has been regarded as the main cause of atherosclerosis. An abnormal accumulation of low-density lipoprotein in the artery wall and, as a result, in the formation of oxide, can lead to atherogenesis. Therefore in present study, the concentration boundary layer of low-density lipoprotein in a straight artery is investigated numerically. The governing equations consist of continuity, momentum conservation, and the particles transport in the blood based on appropriate boundary conditions have been solved using one of the most powerful computational fluid dynamics techniques known as the Projection method. Results are obtained and presented as profiles and contours of concentration, blood velocity and wall shear stress, which are in good agreement with numerical and analytical results of previous studies. Effects of factors such as filtration velocity and wall shear stress on the low-density lipoprotein surface concentration and concentration boundary layer thickness are investigated. The results show that increasing the wall suction (high blood pressure) and reducing the Wall Shear Stress results in an increase in surface concentration. Increasing Reynolds number and Schmidt number decreases the concentration boundary layer thickness, and surface concentration increase about 7% higher than that of the bulk flow.

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References

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Amirkabir Journal of Mechanical Engineering
Volume 52, Issue 11
February 2021
Pages 3143-3154

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