Study of Young’s Modulus and Failure Strength of Polyurethane-Based Binary Polymer Composite Structures Based on Stress-Strain Curve for Tissue Engineering Vascular Graft Application

Document Type : Research Article

Authors

1 Chemical Engineering Department, University of Sistan and Baluchestan, Zahedan, Iran

2 Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran

3 aC Chemical Engineering Department, University of Sistan and Baluchestan, Zahedan, Iran

Abstract

The coronary arteries are of the important cardiovascular diseases. The autograft is the main treatment for this problem, but in many patients, the autografts are not applicable. So, due to a large number of requirements, it needs to find suitable replacements for diseases of blood vessels. Nanomaterial structures are highly contributive in tissue engineering vascular scaffolds due to their ability in mimicking the nanoscale dimension of the natural extracellular matrix and the existing mechanical match between the native vessel and the structure. The aim of this research was developing and mechanically improving nanofibrous hybrid structures using blend electrospinning methods with different ratios of the polyethylene terephthalate, polyurethane and polycaprolactone. The morphological and mechanical properties of all fabricated structures were evaluated. The average fiber diameter, porosity, stress and Young’s modulus changes’ range in composite structures (polycaprolactone/polyurethane and polyethylene terephthalate/polyurethane ) were obtained 343 ± 94 to 382 ± 83 nm, 58.6 ± 3.12 to 81 ± 1.7 %, 2.66 ± 0.39 to 19.05 ± 3.2 MPa and 3.18 ± 0.09 to 41.4± 3.31 MPa, respectively. According to results, the fabricated scaffolds as well as polyethylene terephthalate/polyurethane structure exhibited suitable mechanical and biological properties and clinical requirements as a small-diameter vascular graft.

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Main Subjects

References

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Amirkabir Journal of Mechanical Engineering
Volume 52, Issue 12
March 2021
Pages 3567-3582

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