Image-based numerical model for drug delivery to solid tumors

Document Type : Research Article

Authors

1 Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran

2 Department of Mechanical Engineering, K N Toosi University of Technology, Tehran, Iran

Abstract

Mathematical models and numerical simulations along with clinical studies can help provide better understanding of drug delivery mechanisms, increase the efficacy of therapy, and demonstrate the effect of various physiological parameters on tumor behavior. The main objective of this study is to use a multiscale model based on mathematical modeling and computational fluid dynamics to evaluate drug delivery to a solid tumor and to predict treatment efficacy. A more-realistic physiological model of the tumor compared to the previous models is examined by obtaining the capillary-network’s geometry from an image, as well as by considering the necrotic area and cellular uptake. Fluid flow modeling and drug delivery simulation are then performed for the interstitium. The fraction of killed cells is obtained approximately 69.03% after the cancerous tissue is treated with doxorubicin. Results also demonstrate that the drug concentration in the necrotic area is very low; only a small amount of the drug penetrates into the necrotic area by diffusion. The findings of this study may help researchers better understand the mechanism of drug delivery to solid tumors, —a necessary step in overcoming the micro-environmental barriers of tumors that impede treatment efficacy.

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Main Subjects

References

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Amirkabir Journal of Mechanical Engineering
Volume 53, Issue 5 (Special Issue)
August 2021
Pages 3187-3200

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