عنوان مقاله [English]
In targeted drug delivery, the use of temperature-sensitive microparticles as drug carriers has been the subject of many researchers recently. In one approach, the use of NIPAM microparticles as temperature-sensitive drug carriers can be effective in the topical treatment of chronic, diabetic or burned wounds. In this study, we first fabricated a flow focusing microchannel by photolithography. Then NIPAM solution was made with different percentages and used as the drop phase in the microchannel. The results showed that the use of 10% of NIPAM was successful in the polymerization reaction and the use of NIPAM with a lower percentage didn't show any result in the production of high quality and usable polymers. Thus the NIPAM solutions and silicone oil were used as discrete and continuous phases, respectively, and the NIPAM microparticles were produced through the two-phase flow generated in the microchannel. The effect of flow ratio on the diameter of droplets produced was evaluated using a digital microscope. The results of the study showed that by changing the ratio of discrete phase to continuous phase from 0.14 to 0.84, the droplet diameter increased from 360 to 515 microns. Thus, the microparticles produced in this method can be used as temperature-sensitive drug carriers in the treatment of chronic wounds.