Design and Multi-Objective Optimization of A Magnetohydrodynamic Drug Delivery Infusion Micropump

Document Type : Research Article

Authors

1 Department of Mechanical Engineering, University of Sistan and Baluchestan, Zahedan, Iran.

2 Department of Mechanical Engineering (Mechatronics), University of Sistan and Baluchestan, Zahedan, Iran.

3 Zahedan University of Medical Sciences, Zahedan, Iran.

Abstract

Continuous drug infusion plays an important role in drug effectiveness. However, in most cases, the size, weight, and power consumption of conventional pumps are among the most important factors that cause a lot of problems for patient comfort. The present work aims to design and optimize a Magnetohydrodynamic micropump for continuous drug infusion. A mathematical model of Magnetohydrodynamic micro pump is proposed and solved analytically to investigate its feasibility for drug infusion. For the patient's comfort, the micropump is optimized using non-dominated sorting genetic algorithm II. The number of channel rows and columns, channel height and width, and driving voltage are chosen as decision variables for multi-objective optimization. The Pareto front of the optimization result is presented. Six possible cases that meet the desired specifications are selected using a fuzzy decision-making approach. A computational fluid dynamic model is adopted to predict bubble formation due to the electrolysis phenomena. With higher reliability without any mechanical part, the present design can deliver drug flow 48 times while its driving voltage is 3 times lower than a conventional micro pump. In addition, it provides potentially better reliability and a simple fabrication process without any mechanical parts.

Keywords

References

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Amirkabir Journal of Mechanical Engineering
Volume 53, Issue 10
January 2022
Pages 5221-5238

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