Investigation of the Effect of Different Friction Models On Experimental Extraction of 3D Nanomanipulation Force and Critical Time of Colon Cancer Tissue

Document Type : Research Article

Author

Associate Professor of Mechanical Engineering, Arak University, Arak, Iran

Abstract

Nano-dimensional particle displacement, property improvement, and studies on cellular tissues are some of the applications of the nanomanipulation process using atomic force microscopy. In general, the manipulation process begins with the contact of the needle and the desired cell tissue and with the application of force on the beam. The increase in force will continue until the resistance forces such as friction are overcome. At this time, the critical force and time are recorded. In this article, colon cancer tissue has been studied. The important parameter evaluated in this study is the critical force and time according to different friction models in order to reduce damage to cancerous tissue. Experimental experiments on colorectal cancer tissue have been performed using atomic force microscopy. LuGre, Coulomb, and HK friction models are used in the simulations. Finally, by comparing the force outcome diagrams and considering different friction models, in 3D manipulation, the maximum amount of force and critical time for the Coulomb friction model and the lowest value for the LuGre friction model are recorded. Considering the apparent contact surface at the Nano-dimensions in the Coulomb model and the actual contact surface in the LuGre friction model, these results are justifiable.

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References

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Amirkabir Journal of Mechanical Engineering
Volume 54, Issue 4
July 2022
Pages 791-804

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