Simulation of the Role of the Anti-Angiogenic Therapy in Fluid Flow Behavior and Macromolecule Transport into a Heterogeneous Solid Tumor

Document Type : Research Article

Authors

Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran

Abstract

The present study develops a numerical approach based on the mathematical models governing the behavior of fluid flow and drug transport in tumors to investigate the delivery of a macromolecule under the effect of the vascular normalization into a non-uniform tumor, including different parts of a real solid tumor. In this study, different tumor sizes in the range of  are considered. The area under the curves of the drug average distribution and its deviation in the tumor site over time is studied as the amount of drug delivered and the uniformity of delivered drug to assess the quality of drug delivery. Results show that before and after normalization, the behaviors of interstitial fluid flow and the distribution of therapeutic agent concentration depend on tumor size. Normalization in all sizes reduces the interstitial fluid pressure, which this pressure drop increases as the tumor size reduces. Normalization improves antibody concentration distribution at different times depending on tumor size. However, from the point of view of the average spatiotemporal criterion, vascular normalization improves macromolecule delivery into the tumor site in  by increasing the distribution uniformity. This research, by discussing the mechanisms affecting normalization efficiency, can provide insights for in vivo and in vitro studies that address the combination of anti-angiogenic therapy and chemotherapy.

Keywords

Main Subjects

References

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Amirkabir Journal of Mechanical Engineering
Volume 54, Issue 7
October 2022
Pages 1481-1512

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