Numerical Study of Therapeutic Effectiveness of Bolus Injection and Continuous Infusion on Drug Delivery to Vascularized Solid Tumor

Document Type : Research Article

Authors

1 Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran

2 Department of Mechanical Engineering, K N Toosi University of Technology, Tehran, Iran

Abstract

Effective delivery of drugs to tumor cells is essential for the success of most anticancer therapies. In this study, two-dimensional modeling for spatiotemporal distribution of doxorubicin concentration under bolus injection and the continuous infusion is presented. Mathematical simulations have been performed considering the main physical and biochemical processes in drug delivery to tumor cells. Anticancer effectiveness is evaluated through changes in tumor cell density based on predicted intracellular concentrations. Unlike most computational models, which assume a uniform distribution of blood vessels in the tumor, the vascular network is produced using a sprouting angiogenesis method. The results demonstrate that the drugs accumulate more in areas with high vascular density, resulting in improved drug cytotoxicity. Compared to bolus injection, continuous infusion leads to longer high level maintenance of intracellular drug concentrations in the tumor, which is more effective in improving the cytotoxic effect. Although bolus injection leads to a 90% higher extracellular concentration peak, there is the risk of severe side effects. Also, continuous infusion by keeping doxorubicin at a higher level in the tumor leads to improved anticancer effectiveness by about 26% relative to the effectiveness of bolus injection at the end of the treatment.
 

Keywords

References

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Amirkabir Journal of Mechanical Engineering
Volume 54, Issue 11
February 2023
Pages 2543-2560

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