Optimal laser control for cancer thermal therapy

Document Type : Research Article

Authors

Mechanical Engineering Group, Golpayegan College of Engineering, Isfahan University of Technology

Abstract

Todays, various treatments such as surgery, chemotherapy, radiotherapy, and hyperthermia are used to treat cancer. The best treatment for cancer is to accurately control the distribution of temperature in the damaged tissue, which has been the subject of many studies in recent years. Due to the increased temperature in cancer treatment, and especially in hyperthermia, the healthy tissue adjacent to the damaged tissue also disappears and results in bad consequences. In this paper, the optimal laser control for cancer therapy has been done. According to the non-Fourier behavior of temperature transitions in laser treatments, the time-dependent transient temperature distribution in one-dimensional mode, along with the heat of metabolism and perfusion of blood, using the Pence heat transfer equation, is analyzed. In order to minimize the damage to the healthy tissues adjacent to the damaged tissue, the objective function includes the difference between the calculated thermal damage with the desired thermal damage is defined. Therefore, the thermal flux value is optimized as an optimal control problem, and the lowest and most useful value is obtained. Finally, the results of the numerical solution to this problem are extracted and shown for triangular thermal flux and square heat pulses.

Keywords

Main Subjects

References

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Amirkabir Journal of Mechanical Engineering
Volume 54, Issue 10
January 2023
Pages 2333-2350

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